AOD 9604

What is AOD 9604?

AOD 9604 is a 16-amino-acid synthetic peptide derived from the C-terminal region of human growth hormone (residues 177-191), with an added tyrosine at the N-terminus for improved stability. It was developed to isolate the lipolytic (fat-breaking) effects of hGH while avoiding its growth-promoting, IGF-1 elevating, or glucose-disrupting effects.

It does not bind the growth hormone receptor but is researched for selective activation of beta-3 adrenergic receptors in adipose tissue, promoting fat breakdown (lipolysis) and inhibiting fat storage (lipogenesis).

What Is It Commonly Studied For?

• Fat metabolism and lipolysis — Stimulates breakdown of stored fat in preclinical models
• Body composition — Potential reduction in adipose tissue without affecting lean mass in animal studies
• Metabolic health — No significant impact on IGF-1, blood glucose, or insulin sensitivity observed in trials
• Cartilage and joint health — Some animal/in vitro research on cartilage regeneration
• Obesity models — Modest effects noted in early human Phase IIa studies (~2.6 kg additional weight loss vs placebo over 12 weeks in one trial); larger Phase IIb trial did not meet primary endpoint for significant weight loss

Product Specifications

• Peptide: AOD 9604 (Tyr-hGH 177-191)
• Form: Lyophilized powder (for reconstitution)
• Purity: ≥98–99% (Third-party tested)
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge)
• Molecular Weight: ~1,815 Da
• CAS Number: 221231-10-3
• Storage: Refrigerate after reconstitution

Shipping & Handling

• Ships from Canada
• Discreet packaging — no product names on outside
• Tracking included on all orders
• Free shipping on orders over $250